Linked Life Data

6368732

Source:http://linkedlifedata.com/resource/pubmed/id/6368732

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-5-14
pubmed:abstractText
Progesterone is the hormone that reinitiates the meiotic division of amphibian oocytes and insulin and insulin-like growth factors are also active on defolliculated oocytes in vitro. We have studied Xenopus laevis oocytes (stage 5-6) of different hormonal sensitivities, obtained from unstimulated and from human chorionic gonadotrophin-stimulated females. Some oocytes from unstimulated females were also precultured with a subthreshold level of progesterone. A dose-dependent potentiating effect of the action of progesterone was observed with insulin, and this was particularly remarkable in low-sensitivity oocytes. Since in the presence of insulin, the optimally effective concentration of progesterone was much reduced (as an example from 1 mumol/1 to 50 nmol/l), it is suggested that an insulin-like growth factor may play a physiological role in the reinitiation of meiosis in ovaries.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-0795
pubmed:author
pubmed:issnType
Print
pubmed:volume
101
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7-12
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Induction of germinal vesicle breakdown in Xenopus laevis oocytes: synergistic action of progesterone and insulin.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't