Linked Life Data

6340522

Source:http://linkedlifedata.com/resource/pubmed/id/6340522

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1983-5-27
pubmed:abstractText
In rat fetal islets it was tested whether their failure to respond to glucose with insulin secretion might be due to inadequate changes of the redox state of pyridine nucleotides and of glutathione. In islets of newborn (5 days) and adult (3 mo) rats elevation of glucose produced an increase in insulin secretion, pentose phosphate shunt (PPS) activity, and NADPH/NADP, NADH/NAD, and GSH/GSSG ratios. An increase in the NADH/NAD ratio was also observed in islets of fetal rats, but in contrast to islets of newborns and adults no increase in insulin release, PPS activity, and the GSH/GSSG ratio was observed. However, at all glucose concentrations tested islets of fetal rats exhibited a high NADPH/NADP ratio similar to the ratio of adult rats in the presence of 16.7 mM glucose. It is suggested that in fetal islets there exists a lack of hydrogen transfer from NADPH to GSSG. The high NADPH/NADP ratio may in turn suppress PPS activity. It is possible that the missing insulin release of fetal islets in response to glucose is at least in part due to the fact that the oxidation-reduction state of the GSH/GSSG system also does not respond to the elevation of the glucose concentration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
244
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
E354-60
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Pentose phosphate shunt, pyridine nucleotides, glutathione, and insulin secretion of fetal islets.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't