Linked Life Data

6332784

Source:http://linkedlifedata.com/resource/pubmed/id/6332784

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1984-11-9
pubmed:abstractText
Reaction of 5-bromo-2'-deoxyuridine and dihydropyran in THF gave a tetrahydropyranyl ether derivative which, after treatment with n-butyllithium, was selectively alkylated in situ by [11C]methyl iodide to give [methyl-11C]thymidine and unlabeled 2'-deoxyuridine. The labeled compound can be isolated by HPLC on a reversed phase column in 12 min. The ether derivative is stable which makes it possible to prepare 11C labeled thymidine by organic synthesis in 17-25% radiochemical yield in 30-45 min with radiopurities greater than 99%. In a synthesis with no-carrier-added, a radiochemical yield of 20% was obtained. Carrier added syntheses gave 2.4-4.7 mCi of [11C]thymidine with specific activities of 250-300 mCi/mmol.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0020-708X
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
705-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Selective alkylation of pyrimidyldianions: synthesis and purification of 11C labeled thymidine for tumor visualization using positron emission tomography.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.