Linked Life Data

6326934

Source:http://linkedlifedata.com/resource/pubmed/id/6326934

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-7-9
pubmed:abstractText
Application of gamma-aminobutyric acid (GABA) antagonist drugs (bicuculline, picrotoxinin) to the intermediate region of the ventral surface of the medulla oblongata of gallamine paralyzed, alpha-chloralose anesthetized cats produced a dose-dependent blockade of the baroreceptor reflex. GABA antagonists applied to the rostral and caudal areas did not block the baroreceptor reflex. When strychnine was applied to the ventral medulla, it did not block the baroreceptor reflex. The diffusion of [3H]bicuculline was studied by scintillation counting and autoradiography and found not to penetrate more than 2 mm from the ventral medullary surface. These results suggest that a GABAergic synapse lies within the first 2 mm of the ventral medulla and is involved in baroreceptor modulation of the sympathetic outflow.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
297
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
175-80
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
GABA antagonists applied to the ventral surface of the medulla oblongata block the baroreceptor reflex.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't