Linked Life Data

6325054

Source:http://linkedlifedata.com/resource/pubmed/id/6325054

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-6-19
pubmed:abstractText
Adrenaline 1 micrograms markedly elevated the activity of adenylate cyclase in ventricular tissue of rat hearts. delta 1-THC 25, 50 and 100 micrograms significantly reduced the adenylate cyclase activity with the maximum effect observed with the dose of 25 micrograms. Doses below or above this range did not produce any significant effect on the enzyme activity. Neither delta 6-THC 25 and 100 micrograms nor PVP 400 micrograms had any significant action on adenylate cyclase. The delta 1-THC-induced lowering of the cyclic AMP concentration in ventricular tissue of rat hearts can be explained, at least partly, by its ability to reduce the activity of adenylate cyclase in these tissues. It is suggested that this enzyme inhibition underlies the cardiac depressant action of delta 1-THC.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0305-1870
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
81-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Effects of delta 1- and delta 6-tetrahydrocannabinol on the adenylate cyclase activity in ventricular tissue of the rat heart.
pubmed:publicationType
Journal Article, In Vitro