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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
1977-1-25
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pubmed:abstractText |
Dimercaprol (BAL) administered 1 hr before 111In-bleomycin in the normal BALB/c mouse produced an early preferential hepatic loading of 111In-bleomycin without a loading of the spleen, skin, bone, or muscle. Liver-to-muscle ratios were increased about threefold under the influence of BAL. Liver (c BAL)/liver (s BAL) ratios also increased threefold at 3 hr whereas relative muscle uptake remained at about unity. Indium-111 chloride (colloid, pH 6.5) used as a control did not show a similar increase. The findings suggest that the kinetics and distribution of 111In-bleomycin in the normal BALB/c mouse can be influenced by pretreatment with BAL.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0161-5505
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1083-7
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:62831-Animals,
pubmed-meshheading:62831-Bleomycin,
pubmed-meshheading:62831-Dimercaprol,
pubmed-meshheading:62831-Female,
pubmed-meshheading:62831-Indium,
pubmed-meshheading:62831-Liver Neoplasms,
pubmed-meshheading:62831-Mice,
pubmed-meshheading:62831-Mice, Inbred BALB C,
pubmed-meshheading:62831-Radionuclide Imaging
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pubmed:year |
1976
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pubmed:articleTitle |
Influence of dimercaprol on the early hepatic uptake of 111In-bleomycin in the BALB/c mouse.
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pubmed:publicationType |
Journal Article
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