Linked Life Data

6228572

Source:http://linkedlifedata.com/resource/pubmed/id/6228572

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-2-20
pubmed:abstractText
A previous report indicating reduced glucose metabolism in pancreatic islets isolated from old as compared with young rats was reinvestigated. With a modified islet isolation procedure it was found that islets from 12- to 18-month-old rats had increased glucose use, elevated glucokinase, phosphofructokinase and glucose-6-phosphate dehydrogenase when compared with islets from 2-month-old controls. Glucose-induced insulin release in vitro of islets from the older rats was also improved by the more careful method of islet isolation but did not achieve rates observed with islets from young rats. The data suggest an age-related activation of pancreatic islet cell metabolism, possibly in response to overstimulation by increased peripheral insulin resistance, characteristic of older obese rats.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-1422
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2-6
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Metabolic adaption of pancreatic islet tissue in aging rats.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.