Linked Life Data

6192601

Source:http://linkedlifedata.com/resource/pubmed/id/6192601

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5-6
pubmed:dateCreated
1983-9-23
pubmed:abstractText
Male mice were i.p. injected with two doses (5 & 15 mg/kg body weight) of [1-14C]ethyl-labelled chlorpyrifos. The radioactivity in liver, fat, kidney and urine was measured 6, 24, 48, and 192 h after treatment. Liver RNA and DNA were isolated and hydrolyzed and the bases separated by ion-exchange chromatography. Radioactivity resulting from incorporation and alkylation of RNA and DNA was measured. Labelled 7-ethylguanine was found in RNA hydrolysate which amounted 5.5 X 10(-3) calculated as fraction of the applied dose. In DNA hydrolysate [14C]7-ethylguanine was missing and the major radioactivity was found in two unknown peaks, one of which corresponds to 3 X 10(-2) of the applied dose. The results indicate that the extent of alkylation obtained with chlorpyrifos is high as compared with other organophosphates with methyl esters.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0341-0382
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
461-4
pubmed:dateRevised
2009-6-8
pubmed:meshHeading
pubmed:articleTitle
Bioalkylation of nucleic acids in mice by insecticides. I. Alkylation of liver RNA and DNA by chlorpyrifos.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.