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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1982-10-29
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pubmed:abstractText |
The effects of benzalkonium chloride, chlorbutol,xylometazoline and naphazoline on the ciliary beat frequency of human adenoids and chicken embryo tracheas have been determined and compared. Chlorbutol 0.5% appeared to arrest ciliary motion in both tissues within 5 minutes. Rinsing with Locke Ringer solution (LR) restored the ciliary motion almost completely in both cases. Benzalkonium chloride 0.006% +EDTA 0.1% decreased the ciliary beat frequency 35% for the human tissues and 50% for the chicken tissues after a contact of 20 minutes. In both cases the frequency hardly changed after rinsing with LR. Naphazoline nitrate 0.1% and xylometazoline HCl 0.05% have reversible effects on the ciliary beat frequency of both human adenoids and chicken embryo tracheas. Cilia of human adenoids appeared to be more sensitive for xylometazoline than for naphazoline; whereas cilia of chicken embryo tracheas were more affected by naphazoline than by xylometazoline. The results with human adenoids and chicken embryo tracheas show a correlation (correlation coeff. = 0.82, p less than 0.005). In the initial response the differences in sensitivity to preservatives and drugs were in many cases statistically significant, but the final effects were similar.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzalkonium Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Chlorobutanol,
http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Naphazoline,
http://linkedlifedata.com/resource/pubmed/chemical/Nasal Decongestants,
http://linkedlifedata.com/resource/pubmed/chemical/xylometazoline
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0300-0729
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
81-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6180466-Adenoids,
pubmed-meshheading:6180466-Animals,
pubmed-meshheading:6180466-Benzalkonium Compounds,
pubmed-meshheading:6180466-Chick Embryo,
pubmed-meshheading:6180466-Child,
pubmed-meshheading:6180466-Chlorobutanol,
pubmed-meshheading:6180466-Cilia,
pubmed-meshheading:6180466-Humans,
pubmed-meshheading:6180466-Imidazoles,
pubmed-meshheading:6180466-Naphazoline,
pubmed-meshheading:6180466-Nasal Decongestants,
pubmed-meshheading:6180466-Trachea
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pubmed:year |
1982
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pubmed:articleTitle |
Correlation between the sensitivity of the ciliary beat frequency of human adenoid tissue and chicken embryo tracheas for some drugs.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro
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