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rdf:type |
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lifeskim:mentions |
umls-concept:C0030705,
umls-concept:C0038013,
umls-concept:C0040300,
umls-concept:C0205369,
umls-concept:C0449432,
umls-concept:C0699040,
umls-concept:C1179435,
umls-concept:C1524073,
umls-concept:C1548799,
umls-concept:C1704711,
umls-concept:C1705248
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pubmed:issue |
1
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pubmed:dateCreated |
1982-2-12
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pubmed:abstractText |
In this paper, we report the presence on Epstein-Barr virus-transformed lymphoblastoid cell lines on platelets and on fibroblasts of an HLA-B27-associated cell surface complex (antigenically related to some antigens of Klebsiella K43 and K21) which is identical to or cross-reactive with the determinant present on the peripheral blood lymphocytes (PBL) of B27-positive patients with ankylosing spondylitis (AS). By contrast, no Klebsiella K43 markers could be demonstrated on the spermatozoa of B27+ AS+ individuals even though these cells expressed the HLA-B27 alloantigen. No B27-associated K43 antigen was detected on the erythrocytes of patients or of normal controls. The B27-associated membrane marker is still detectable on lymphoblastoid cell lines after 20 generations and on fibroblasts after about 10 generations. This finding implies that the continued expression of Klebsiella-modified B27 structure is generally determined and does not require the repeated exposure of the cell surface to Klebsiella antigen. These data suggest that certain non-lymphoid as well as lymphoid cells may be involved in the complex sequence of events leading to the clinical manifestation of AS.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6171370-163715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6171370-348130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6171370-4344316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6171370-4506240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6171370-4545916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6171370-5409969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6171370-5779102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6171370-6157768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6171370-639340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6171370-6989046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6171370-7008798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6171370-7021488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6171370-7354870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6171370-7381924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6171370-910095
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0009-9104
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
158-64
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6171370-Blood Platelets,
pubmed-meshheading:6171370-Cell Membrane,
pubmed-meshheading:6171370-Cells, Cultured,
pubmed-meshheading:6171370-Cross Reactions,
pubmed-meshheading:6171370-Cytotoxicity, Immunologic,
pubmed-meshheading:6171370-Epitopes,
pubmed-meshheading:6171370-Fibroblasts,
pubmed-meshheading:6171370-HLA Antigens,
pubmed-meshheading:6171370-HLA-B27 Antigen,
pubmed-meshheading:6171370-Humans,
pubmed-meshheading:6171370-Klebsiella,
pubmed-meshheading:6171370-Lymphocytes,
pubmed-meshheading:6171370-Male,
pubmed-meshheading:6171370-Spermatozoa,
pubmed-meshheading:6171370-Spondylitis, Ankylosing
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pubmed:year |
1981
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pubmed:articleTitle |
The distribution of a specific HLA-B27-associated cell surface component on the tissues of patients with ankylosing spondylitis.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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