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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1984-2-24
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pubmed:abstractText |
In the isolated frog spinal cord perfused with kainic acid (KA, 5 X 10(-4) M) containing Ringer's solution, within 2 hr there were increases in the amplitude of the dorsal root depolarization, as induced by the GABA-agonists. KA perfusion produced increases in the specific binding of [3H]muscimol to crude synaptic membranes and incubation with KA for 3 hr did not increase [3H]muscimol binding. [3H]GABA was released from KA-treated spinal cord slices in the presence of high K+. KA-induced supersensitivity of the dorsal root to GABA may relate to direct actions on primary afferent terminals and not to denervation of GABAergic neurons.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0742-8413
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
231-6
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pubmed:dateRevised |
2007-7-23
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pubmed:meshHeading |
pubmed-meshheading:6140100-Animals,
pubmed-meshheading:6140100-Electrophysiology,
pubmed-meshheading:6140100-Kainic Acid,
pubmed-meshheading:6140100-Muscimol,
pubmed-meshheading:6140100-Perfusion,
pubmed-meshheading:6140100-Pyrrolidines,
pubmed-meshheading:6140100-Rana catesbeiana,
pubmed-meshheading:6140100-Receptors, Cell Surface,
pubmed-meshheading:6140100-Receptors, GABA-A,
pubmed-meshheading:6140100-Spinal Cord,
pubmed-meshheading:6140100-gamma-Aminobutyric Acid
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pubmed:year |
1983
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pubmed:articleTitle |
Supersensitivity of the GABA receptor in the frog spinal cord, as induced by kainic acid.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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