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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1985-4-16
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pubmed:abstractText |
The specific binding of [3H]kainic acid to hippocampal membranes was examined autoradiographically in rats kindled by tetanic stimulation of the amygdala or angular bundle. One day after the last of 3 class 4-5 kindled seizures, the specific binding of [3H]kainic acid in stratum lucidum of area CA3 was 47-61% less than in electrode-implanted unstimulated controls. Specific binding in the inner third of the dentate molecular layer was reduced to a lesser degree. These observations demonstrate that kainic acid receptors are down-regulated by kindling stimulation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
323
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
128-31
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6098330-Amygdala,
pubmed-meshheading:6098330-Animals,
pubmed-meshheading:6098330-Autoradiography,
pubmed-meshheading:6098330-Electric Stimulation,
pubmed-meshheading:6098330-Hippocampus,
pubmed-meshheading:6098330-Kainic Acid,
pubmed-meshheading:6098330-Kindling, Neurologic,
pubmed-meshheading:6098330-Limbic System,
pubmed-meshheading:6098330-Male,
pubmed-meshheading:6098330-Pyrrolidines,
pubmed-meshheading:6098330-Rats,
pubmed-meshheading:6098330-Rats, Inbred Strains,
pubmed-meshheading:6098330-Receptors, Kainic Acid,
pubmed-meshheading:6098330-Receptors, Neurotransmitter
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pubmed:year |
1984
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pubmed:articleTitle |
Reduced kainic acid binding in rat hippocampal formation after limbic kindling.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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