Linked Life Data

6093209

Source:http://linkedlifedata.com/resource/pubmed/id/6093209

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1984-12-20
pubmed:abstractText
Thirty-seven samples of human primary breast cancer were processed for direct cloning in methylcellulose (MC) cultures. Out of the 37 specimens plated, 19 (51%) tumors grew with a plating efficiency (PE) of 0.012%. Both growing and nongrowing tumors belonged mostly to the ductal histological type. Neither the use of autologous serum (AS) nor of fetal calf serum (FCS) affected the PE. Moreover, a negative correlation was found between the level of estrogens and especially of progestin receptors and the ability of tumors to grow in MC culture. These findings underline the difficulty of cloning fresh specimens of human solid tumors and indicate that malignant cells displaying high concentrations of progestinic receptors may also display a degree of differentiation which leads to a reduced clonogenic ability.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0080-0015
pubmed:author
pubmed:issnType
Print
pubmed:volume
94
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
276-82
pubmed:dateRevised
2008-2-13
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Relationship of steroid hormone receptors to the cloning of fresh breast cancer tissues.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't