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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1979-6-26
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pubmed:abstractText |
1. Acetylcholine and nicotine were superfused on the ventral medullary surface between the ponto-medullary border and C1 in anaesthetized cats in order to determine the topical distribution of their actions on respiration and circulation. 2. Acetylcholine (10(-4) g . ml-1 = 5.5 . 10(-4) mMol . ml-1) produced an increase in respiration and a lowering of blood pressure. The magnitude and the time course of the responses varied according to the points of superfusion on the surface. 3. Nicotine (10(-4) g . ml-1 = 6.2 . 10(-4) mMol . ml-1) elicited hyperventilation and more often an increase in arterial pressure on unilateral superfusion of the surface. In some cases, however, a drop in blood pressure was also observed. 4. The responsive regions of the surface on which nicotine acted and elicited hyperventilation, bear a close resemblance to the regions responsive to acetylcholine. 5. The topographical distribution of the respiratory effects elicited by the above-mentioned drugs were similar to the distribution of the responses to changes in pH on the ventral medullary surface or to electrical stimulation. 6. Procaine (2 . 10(-2) g . ml-1 = 7.3 . 10(-2) mMol . ml-1) applied bilaterally in the intermediate zone (S) caused profound inhibition of respiration and of arterial pressure. Procaine at this concentration also inhibited respiratory hyperventilation caused by nicotine (10(-4) g . ml-1 = 6.2 . 10(-4) mMol . ml-1) applied to the caudal and rostral areas.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0031-6768
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
379
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
19-27
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:571101-Acetylcholine,
pubmed-meshheading:571101-Animals,
pubmed-meshheading:571101-Blood Pressure,
pubmed-meshheading:571101-Brain Mapping,
pubmed-meshheading:571101-Cats,
pubmed-meshheading:571101-Medulla Oblongata,
pubmed-meshheading:571101-Nicotine,
pubmed-meshheading:571101-Procaine,
pubmed-meshheading:571101-Respiration
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pubmed:year |
1979
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pubmed:articleTitle |
Topography of the respiratory and circulatory responses to acetylcholine and nicotine on the ventral surface of the medulla oblongata.
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pubmed:publicationType |
Journal Article,
Comparative Study
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