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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1968-9-25
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pubmed:abstractText |
1. Sample from the neocortex and piriform cortex of guinea pigs and rats were incubated in inulin-containing glucose-saline. Their intracellular (non-inulin) space contained 19-27muequiv. of Na(+)/g. of original tissue. These values were stable between 30 and 100min. after incubation commenced, but addition of (22)NaCl to the neocortical samples showed them to be associated with a flux of 400muequiv. of Na(+)/g. of tissue/hr. 2. Addition of 0.5-10mm-l-glutamic acid or 0.1mm-N-methyl-dl-aspartic acid rapidly increased the tissue's Na(+) content; N-acetyl-dl-aspartic acid was without action. 3. During the first 1-1.5min. after the addition of l-glutamic acid to neocortical samples their Na(+) content increased at 600muequiv./g. of tissue/hr., and the rate of (22)Na(+) influx corresponded to 1230muequiv. of Na(+)/g./hr. These rates were calculated to be sufficiently rapid to account for loss of the tissue's normal membrane potential within 1-2sec. of the addition of the acid. 4. In addition, a rapid but more limited loss of K(+) took place after the addition of l-glutamic acid or the methylaspartic acid; on continued incubation tissue K(+) content increased, as also did the intracellular volume of the tissue, from its original 670mul./g. to 1100mul./g. 5. Interpretation of these and of associated changes is offered in terms that involve a cation pump and the permeability changes associated with the nerve impulse.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/5665890-13718948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5665890-13924913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5665890-14035891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5665890-14286354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5665890-14340077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5665890-14340078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5665890-14791336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5665890-5321711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5665890-5914903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5665890-5924665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5665890-5962016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5665890-6051427
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
108
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
269-74
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:5665890-Amino Acids,
pubmed-meshheading:5665890-Animals,
pubmed-meshheading:5665890-Aspartic Acid,
pubmed-meshheading:5665890-Biological Transport,
pubmed-meshheading:5665890-Brain Chemistry,
pubmed-meshheading:5665890-Cerebral Cortex,
pubmed-meshheading:5665890-Glucose,
pubmed-meshheading:5665890-Glutamates,
pubmed-meshheading:5665890-Guinea Pigs,
pubmed-meshheading:5665890-Inulin,
pubmed-meshheading:5665890-Membrane Potentials,
pubmed-meshheading:5665890-Potassium,
pubmed-meshheading:5665890-Rats,
pubmed-meshheading:5665890-Sodium,
pubmed-meshheading:5665890-Sodium Chloride,
pubmed-meshheading:5665890-Sodium Isotopes,
pubmed-meshheading:5665890-Water-Electrolyte Balance
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pubmed:year |
1968
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pubmed:articleTitle |
Excitatory acidic amino acids and the cation content and sodium ion flux of isolated tissues from the brain.
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pubmed:publicationType |
Journal Article
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