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Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
|
pubmed:dateCreated |
1980-2-26
|
pubmed:abstractText |
In vitro effects of d,l-methadone and morphine on [3H]serotonin (3H-5-HT) uptake in rat periaqueductal gray (PAG) slices were investigated. Only methadone had a significant inhibitory effect on 3H-5-HT uptake which was significantly enhanced by naloxone. The systemic administration of methadone did not affect 3H-5-HT uptake in vitro. These data further weaken the possible relationship between narcotic analgesia and blockade of the 5-HT reuptake mechanism.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0014-2999
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
26
|
pubmed:volume |
59
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
107-10
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pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:510390-Animals,
pubmed-meshheading:510390-Brain,
pubmed-meshheading:510390-Cerebral Aqueduct,
pubmed-meshheading:510390-Male,
pubmed-meshheading:510390-Methadone,
pubmed-meshheading:510390-Morphine,
pubmed-meshheading:510390-Naloxone,
pubmed-meshheading:510390-Rats,
pubmed-meshheading:510390-Serotonin
|
pubmed:year |
1979
|
pubmed:articleTitle |
Effect of methadone and morphine on serotonin uptake in rat periaqueductal gray slices.
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pubmed:publicationType |
Journal Article,
In Vitro
|