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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1979-11-21
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pubmed:abstractText |
The effects of protamine on left ventricular (LV) function were measured under conditions of controlled heart rate and proximal aortic pressure in eight anaesthetized, heparinised dogs. Protamine 3 mg.kg-1 produced a 21% decrease in LV dP/dt max, a 43% decrease in cardiac output, a 47% decrease in stroke work and decreases in systolic and diastolic pressures (-16%, -19% respectively). Protamine 6 mg.kg-1 resulted in a 17% decrease in LV dP/dt max, a 26% decrease in cardiac output, a 50% decrease in LV stroke work and 25 and 30% decreases in systolic and diastolic pressures. These results show that an impairment of LV function plays an important part in the circulatory depression produced by protamine.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0008-6363
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
254-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:476745-Animals,
pubmed-meshheading:476745-Blood Pressure,
pubmed-meshheading:476745-Cardiac Output,
pubmed-meshheading:476745-Dogs,
pubmed-meshheading:476745-Heart,
pubmed-meshheading:476745-Heart Ventricles,
pubmed-meshheading:476745-Heparin,
pubmed-meshheading:476745-Protamines,
pubmed-meshheading:476745-Vascular Resistance,
pubmed-meshheading:476745-Ventricular Function
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pubmed:year |
1979
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pubmed:articleTitle |
Effects of heparin and protamine on left ventricular performance in the dog.
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pubmed:publicationType |
Journal Article
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