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rdf:type |
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lifeskim:mentions |
umls-concept:C0013295,
umls-concept:C0017119,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0030705,
umls-concept:C0030859,
umls-concept:C0036534,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1998602,
umls-concept:C2911692
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pubmed:issue |
11
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pubmed:dateCreated |
1974-2-7
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pubmed:abstractText |
The inhibitory effects of intravenous secretion on the gastric acid responses to a meal and to pentagastrin were studied in seven duodenal ulcer patients.A test meal of 10% peptone adjusted to pH 5.0 was introduced into the stomach and the Fordtran and Walsh method was used to measure the gastric acid output by monitoring the rate at which a solution of 0.3 M sodium bicarbonate had to be added to keep the pH of the gastric content constant at the value of 5.0. A constant dose of secretin (1 U/kg-hr) significantly depressed the serum gastrin response to a meal and produced an inhibition of acid secretion by about 70% of the control level. Secretin inhibited the acid response induced by pentagastrin by about 60% and simultaneously provoked a pancreatic bicarbonate output sufficient to neutralize about 60% of the gastric acid output to pentagastrin. We conclude that secretin is a strong inhibitor of gastric secretion in duodenal ulcer patients induced by a meal and by pentagastrin.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4761603-14184350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4761603-4559392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4761603-4685087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4761603-4893733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4761603-4922127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4761603-5073222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4761603-5212382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4761603-5441886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4761603-5460746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4761603-5554500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4761603-5680900
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0017-5749
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
842-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:4761603-Adult,
pubmed-meshheading:4761603-Bicarbonates,
pubmed-meshheading:4761603-Duodenal Ulcer,
pubmed-meshheading:4761603-Food,
pubmed-meshheading:4761603-Gastric Juice,
pubmed-meshheading:4761603-Gastrins,
pubmed-meshheading:4761603-Humans,
pubmed-meshheading:4761603-Hydrogen-Ion Concentration,
pubmed-meshheading:4761603-Middle Aged,
pubmed-meshheading:4761603-Pentagastrin,
pubmed-meshheading:4761603-Secretin,
pubmed-meshheading:4761603-Secretory Rate
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pubmed:year |
1973
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pubmed:articleTitle |
Inhibition by secretin of the gastric acid responses to meals and to pentagastrin in duodenal ulcer patients.
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pubmed:publicationType |
Journal Article
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