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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1973-4-16
|
| pubmed:abstractText |
Two deficiencies for, and a dominant enhancer of, the second chromosome maternal effect mutant, "daughterless" (da), were induced with X-irradiation. Their properties were studied with respect to both da and the linked maternal effect mutant, "abnormal oocyte" (abo), with the following conclusions. (1) The most probable map positions of da and abo are: J-(1/2)-da-2(1/2)-abo, where J is a dominant marker located at 41 on the standard map. (2) The da locus is in bands 31CD-F on the polytene chromosome map; abo is to the right of 32A. (3) Because homozygous da individuals survive while individuals carrying da and a deficiency for da are lethal, it is concluded that da is hypomorphic. (4) From a weak da-like maternal effect in heterozygous da females induced by an "Enhancer of da," we have confirmed a previous report that (a) the amount of sex chromosome heterochromatin contributed by the father can influence the severity of the da maternal effect, and (b) the sex chromosome heterochromatin which influences the da effect is different from that which influences the abo effect. (5) The possibility that da and abo are in a special region of chromosome 2 concerned with the regulation of sex chromosome heterochromatin is strengthened by the observation that the Enhancer of da appears to rescue abnormal eggs produced by homozygous abo mothers. (6) The Enhancer of da is a translocation between chromosomes 2 and 3 with the second chromosome breakpoint in the basal heterochromatin; because the enhancing effect maps in this region of chromosome 2, it is possible that autosomal, as well as sex chromosomal, heterochromatin interacts with da and abo.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0016-6731
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
73
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
73-86
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| pubmed:dateRevised |
2010-9-10
|
| pubmed:meshHeading |
pubmed-meshheading:4631602-Alleles,
pubmed-meshheading:4631602-Animals,
pubmed-meshheading:4631602-Chromosome Mapping,
pubmed-meshheading:4631602-Drosophila melanogaster,
pubmed-meshheading:4631602-Female,
pubmed-meshheading:4631602-Heterochromatin,
pubmed-meshheading:4631602-Homozygote,
pubmed-meshheading:4631602-Male,
pubmed-meshheading:4631602-Mutation,
pubmed-meshheading:4631602-Ovum,
pubmed-meshheading:4631602-Radiation Genetics,
pubmed-meshheading:4631602-Sex Chromosomes
|
| pubmed:year |
1973
|
| pubmed:articleTitle |
A note on the maternal effect mutants daughterless and abnormal oocyte in Drosophila melanogaster.
|
| pubmed:publicationType |
Journal Article
|