Linked Life Data

4087373

Source:http://linkedlifedata.com/resource/pubmed/id/4087373

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1986-3-4
pubmed:abstractText
Using a Langendorff rat heart preparation, we examined effects of nicardipine, a calcium channel blocker, on different stages of ischemic damage, characterized by a development of contracture and leakage of intracellular enzymes. Maximum recoveries of heart rate (HR) and peak left ventricular pressure-HR product after 20 min ischemia were attenuated by about 25% compared with those before ischemia. When nicardipine (0.1 mumol) was added to the perfusate 5 min prior to ischemia, this mechanical failure recovered completely to the pre-ischemic level. Although a significant increase in left ventricular end-diastolic pressure was observed in hearts exposed to 30 min ischemia, the amount of creatine kinase (CK) released during re-flow after 30 min ischemia was not enhanced by contracture but was proportional to the duration of ischemia (compared with that of 20 min ischemia). Nicardipine reduced CK leakage by 25% after 30 min ischemia but did not alter either ATP levels or coronary flow. The beneficial effects of nicardipine on ischemic damage are probably related to inhibition of calcium influx (Terai et al: Biochem Pharmacol 30: 375, 1981), which may accompany reperfusion of ischemic myocardium.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0021-4868
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
813-21
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Effects of nicardipine on ischemic mechanical failure and tissue injury in isolated perfused rat heart.
pubmed:publicationType
Journal Article