Linked Life Data

4068701

Source:http://linkedlifedata.com/resource/pubmed/id/4068701

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1986-1-14
pubmed:abstractText
Three adult male rhesus monkeys were castrated and administered 2 mCi [3H]dihydrotestosterone ([3H]DHT) intravenously. Brain and peripheral organs were removed after 60 min and were examined either by thaw-mount autoradiography or by subcellular fractionation and high performance liquid chromatography. Neurons that accumulated radioactivity in their nuclei were distributed widely in many regions of the brain including the preoptic area, hypothalamus, septal area-bed nucleus, amygdala, thalamus, and brain stem. Several brain areas which were labeled after [3H]DHT injection had not been labeled in earlier experiments after [3H]testosterone ([3H]T) injection. The major metabolite of [3H]DHT in extranuclear fractions from brain was [3H]androstanediol, but [3H]DHT alone was detected in cell nuclei. There was no evidence of any [3H]estradiol in cell nuclei, confirming that DHT can also be regarded as a non-aromatizable androgen in the primate brain. Since the nuclear concentrations of androgens were 2-3 times higher in the brain following [3H]DHT than they were in the earlier [3H]T experiments, the relative lack of effectiveness of DHT in restoring the sexual behavior of male castrates cannot be related to an inability of DHT to enter brain cell nuclei.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-4731
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
389-98
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
The distribution, nuclear uptake and metabolism of [3H]dihydrotestosterone in the brain, pituitary gland and genital tract of the male rhesus monkey.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't