Linked Life Data

4053021

Source:http://linkedlifedata.com/resource/pubmed/id/4053021

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11 Pt 1
pubmed:dateCreated
1985-12-2
pubmed:abstractText
In this study the relationships between sister chromatid exchange (SCE) frequency, mutation induction at the hypoxanthineguanine phosphoribosyl transferase locus, and cell survival were established in Chinese hamster ovary cells exposed to one of the three N-oxidized arylamines. The toxicants used were N-hydroxy-2-aminofluorene, N-hydroxy-N'-acetylbenzidine, and 1-nitrosopyrene. Mutation induction as measured by resistance to 6-thioguanine related poorly to reduced cloning ability and SCE frequency. Although SCEs were formed at concentrations of toxicants which produced no measurable reduction in cell survival, a strong correlation was observed between these two biological responses. This relationship was strengthened when the results obtained in this study were combined with those from a previous study which examined the relationship between SCE induction and cell survival in Chinese hamster ovary cells exposed to simple alkylating agents. These results support the contention that a common step is involved in the induction of SCE and cellular toxicity in Chinese hamster ovary cells exposed to certain classes of chemical toxicants.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5461-5
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Correlation of sister chromatid exchange frequency with mutation induction and cell survival in Chinese hamster ovary cells exposed to N-oxidized arylamines.
pubmed:publicationType
Journal Article