Linked Life Data

4008472

Source:http://linkedlifedata.com/resource/pubmed/id/4008472

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-7-31
pubmed:abstractText
During the generation of primer for transcription initiation by endonucleolytic cleavage of capped RNA, the influenza virus-associated RNA-dependent RNA polymerase recognizes three signals of capped RNA, i.e., cap-1 structure at 5' termini, RNA sequences at the cleavage sites, and distance between these two signals (Plotch, S.J., Bouloy, M., & Krug, R.M. (1979) Proc. Natl. Acad. Sci. U.S. 76, 1618-1622; Kawakami, K., Mizumoto, K., & Ishihama, A. (1983) Nucl. Acids Res. 11, 3637-3649). The free cap-1 structure, i.e., m7GpppNm not associated with polynucleotides, stimulates the RNA synthesis as well, irrespective of the presence or absence of dinucleotide primers. Since the stimulation by m7GpppNm and ApG is additive and the free cap-1 structure is not incorporated into 5' termini of product RNA, we propose that the cap-1 structure stimulates the RNA polymerase by allosteric modulation rather than by priming the transcription initiation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0021-924X
pubmed:author
pubmed:issnType
Print
pubmed:volume
97
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
655-61
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Activation of influenza virus-associated RNA polymerase by cap-1 structure (m7GpppNm).
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't