Linked Life Data

4002784

Source:http://linkedlifedata.com/resource/pubmed/id/4002784

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1985-7-25
pubmed:abstractText
The authors have compared the clinical and metabolic effects of two high ceiling diuretics, muzolimine (M) and furosemide (F), by i.v. and oral routes in 40 patients classified in four groups with different degrees of renal failure. The study demonstrated a more pronounced effectiveness of M than F by oral administration, while it appeared equal to F when given i.v. The urine volume and Na+ excretion were significantly increased during M treatment compared to oral F in each group. Calcium urinary excretion was reduced with M while P was increased compared with F. BUN, creatinine and uric acid were temporarily increased in the 3rd and 4th groups, probably due to extracellular fluid volume contraction, associated also with transient change in GFR. M at a lower dosage than F has demonstrated an effective diuretic response irrespective the degree of renal impairment. From its pharmacological properties, M appears a safe and active diuretic agent, particularly at a high dosage in patients with severe renal failure, and is notable for its lack of important side effects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-5860
pubmed:author
pubmed:issnType
Print
pubmed:volume
74 Suppl 2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
115-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Step-dose of muzolimine at different stages of chronic renal failure: comparison with furosemide.
pubmed:publicationType
Journal Article, Comparative Study