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Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1985-4-1
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pubmed:abstractText |
The plasma lipoproteins of a 1-year-old Japanese infant were studied because of malnutrition, severe decrease in plasma lipid level, and acanthocytosis. Plasma lipoprotein analysis revealed that low-density lipoproteins were deficient; however, low levels of triglyceride-rich lipoproteins were found in the plasma. On sodium dodecylsulfate (SDS) polyacrylamide gel electrophoresis, apoprotein B-48 and a faint band corresponding to apoprotein B-100 were detected in the lipoprotein fraction of density less than 1.006 g/mL when the infant was 6 months old. Apoprotein B-48 was more clearly detected after 1 year, but the band corresponding to apoprotein B-100 on the sodium dodecylsulfate gel electrophoresis had disappeared. The apoprotein B-48 content of the fraction with density less than 1.006 g/mL was about 0.05 to 0.3 mg/dL. The patient's lipoproteins consisted mainly of high-density lipoproteins. These results suggest that the disorder in this patient is caused by apoprotein B-100 deficiency.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0031-4005
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
541-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3975124-Abetalipoproteinemia,
pubmed-meshheading:3975124-Acanthocytes,
pubmed-meshheading:3975124-Adult,
pubmed-meshheading:3975124-Apolipoprotein B-100,
pubmed-meshheading:3975124-Apolipoproteins B,
pubmed-meshheading:3975124-Biological Transport,
pubmed-meshheading:3975124-Chromatography, High Pressure Liquid,
pubmed-meshheading:3975124-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:3975124-Female,
pubmed-meshheading:3975124-Humans,
pubmed-meshheading:3975124-Infant,
pubmed-meshheading:3975124-Lipoproteins,
pubmed-meshheading:3975124-Male,
pubmed-meshheading:3975124-Microscopy, Electron, Scanning,
pubmed-meshheading:3975124-Triglycerides
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pubmed:year |
1985
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pubmed:articleTitle |
Normotriglyceridemic abetalipoproteinemia in infancy: an isolated apolipoprotein B-100 deficiency.
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pubmed:publicationType |
Journal Article,
Case Reports
|