Linked Life Data

3958802

Source:http://linkedlifedata.com/resource/pubmed/id/3958802

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1986-5-22
pubmed:abstractText
Two-month-old, male ferrets were fasted for 16 h and fed a synthetic, arginine-free diet. Within 2-3 h after ingesting the diet, they developed hyperammonemia and encephalopathy. Ammonia levels in the serum, brain and cerebrospinal fluid were greatly elevated compared to those of ferrets fed the synthetic diet supplemented with arginine. Orotic acid and glucose levels in serum were also significantly elevated. Urinary orotic acid was significantly increased but citrate and creatinine level were unaltered. Adult (18-mo-old) ferrets did not develop hyperammonemia and encephalopathy after eating the arginine-free diet. Serum and urinary orotic acid levels were significantly elevated in the adult ferrets fed arginine-free diet. Hyperammonemia and encephalopathy were prevented in young ferrets by supplying dietary arginine and abbreviated by ornithine injections given during encephalopathy. These results suggest that young ferrets are unable to meet their ornithine needs from precursors other than arginine, whereas adult ferrets appear to be able to synthesize ornithine from sources other than dietary arginine. Intraperitoneal injection of sodium benzoate to young ferrets fed arginine-free diet failed to decrease serum ammonia levels.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-3166
pubmed:author
pubmed:issnType
Print
pubmed:volume
116
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
545-51
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Effect of arginine-free diet on ammonia metabolism in young and adult ferrets.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.