Linked Life Data

3935329

Source:http://linkedlifedata.com/resource/pubmed/id/3935329

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3 Pt 2
pubmed:dateCreated
1986-2-11
pubmed:abstractText
We have constructed and transformed into the D. melanogaster germ line a series of hsp26 deletion variants. We show that the region -728 to +14 contains all of the cis-acting sequences necessary for the developmental and heat-inducible transcription of hsp26. Sequences upstream of -341 are not required for heat-inducible expression but are required for ovarian expression. Conversely, sequences between -351 and -53 are unnecessary for ovarian expression but are needed for maximal heat-inducible expression. We conclude that most, or all, of the cis-acting regulatory sequences required for hsp26 gene expression during oogenesis are physically separable from those required for heat-inducible expression. These results suggest that different trans-acting factors bind at different regulatory sites in the 5'-flanking region of the gene, thus activating its transcription.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0092-8674
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
737-46
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Separate regulatory elements for the heat-inducible and ovarian expression of the Drosophila hsp26 gene.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.