Linked Life Data

3899858

Source:http://linkedlifedata.com/resource/pubmed/id/3899858

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1985-11-1
pubmed:abstractText
Immunoreactive insulin levels (IRI) were measured by a homologous fish insulin radioimmunoassay. An in vitro pancreatic islet superfusion technique was employed to monitor the changes in IRI in the presence and absence of specific adrenergic agonists and antagonists. Exogenous adrenaline at low concentrations (10(-10) M) inhibited IRI release but evoked an IRI stimulation at high concentrations (10(-6) M). The stimulation of IRI by adrenaline is thought to involve beta-adrenoceptors located postsynaptically on the beta-cell membrane as the effect of adrenaline was mimicked by the beta-agonist, isoproterenol, and abolished by the beta-antagonist, propranolol. Phentolamine (an alpha-antagonist) potentiated the adrenergic stimulation of IRI, whereas yohimbine (an alpha 2-antagonist) was without effect. Phenylephrine (alpha 1-adrenoceptor agonist) inhibited IRI release suggesting the presence of alpha 1-inhibitory adrenoceptors which exert a modulatory influence on adrenaline-stimulated insulin release.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0016-6480
pubmed:author
pubmed:issnType
Print
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
460-7
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Adrenergic control of insulin release from isolated islet tissue in the rainbow trout, Salmo gairdneri R.
pubmed:publicationType
Journal Article, In Vitro