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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1985-10-22
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pubmed:abstractText |
Fluorescent antinuclear antibody (ANA) testing was performed on 141 sera from 114 patients with well defined rheumatic diseases including fibrositis syndrome and 24 sera from 24 healthy subjects using HEp-2 cells and rat liver as substrates. ANA titers were almost always higher on HEp-2, in most cases by 1:5 dilutions. ANA positivity or negativity was usually substrate independent, but there were exceptions. Two patients with SLE were ANA positive on HEp-2 only and rat liver only, respectively; patterns were homogeneous. Thirteen of 15 CREST patients had anticentromere antibodies, detected on HEp-2 only. "False-positive" ANA were invariably low titer, speckled and confined to one substrate.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
|
pubmed:issn |
0315-162X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
265-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:3897534-Animals,
pubmed-meshheading:3897534-Antibodies, Antinuclear,
pubmed-meshheading:3897534-Cells, Cultured,
pubmed-meshheading:3897534-Epithelial Cells,
pubmed-meshheading:3897534-Epithelium,
pubmed-meshheading:3897534-Evaluation Studies as Topic,
pubmed-meshheading:3897534-Fluorescent Antibody Technique,
pubmed-meshheading:3897534-Humans,
pubmed-meshheading:3897534-Liver,
pubmed-meshheading:3897534-Rats,
pubmed-meshheading:3897534-Skin,
pubmed-meshheading:3897534-Substrate Specificity
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pubmed:year |
1985
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pubmed:articleTitle |
Clinical comparison of cultured human epithelial cells and rat liver as substrates for the fluorescent antinuclear antibody test.
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pubmed:publicationType |
Journal Article,
Comparative Study
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