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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1986-12-30
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pubmed:abstractText |
The apolipoprotein B-100 (apoB-100) gene in leukocytes and the apoB-100 messenger RNA (mRNA) and translated apolipoprotein in the livers from normal and abetalipoproteinemic individuals were evaluated. Four complementary DNA probes for apoB-100 covering the 5', middle, and 3' regions of the apoB-100 mRNA were utilized and Southern blot analysis indicated that the apoB-100 gene is present in abetalipoproteinemia without major insertions or deletions. Polyadenylated hepatic apoB-100 mRNA from two abetalipoproteinemic patients was normal in size, and the concentration of apoB-100 mRNA was increased sixfold compared with control hepatic apoB-100 mRNA levels. ApoB-100 was detected in hepatocytes of abetalipoproteinemic patients by immunohistochemical techniques. These results indicate that the biochemical defect in abetalipoproteinemic patients studied is most consistent with a posttranslational defect in apoB-100 processing or secretion with an up-regulation of the apoB-100 mRNA.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3782476-13745738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3782476-13770408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3782476-14237436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3782476-15411425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3782476-17121392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3782476-175902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3782476-177043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3782476-2989800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3782476-3001697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3782476-3840371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3782476-4305087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3782476-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3782476-5864979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3782476-6099394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3782476-6159641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3782476-6186232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3782476-6204550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3782476-6326713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3782476-6813184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3782476-6959555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3782476-7229035
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1707-12
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1986
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pubmed:articleTitle |
Analysis of the apolipoprotein B gene and messenger ribonucleic acid in abetalipoproteinemia.
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pubmed:publicationType |
Journal Article
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