Linked Life Data

3777462

Source:http://linkedlifedata.com/resource/pubmed/id/3777462

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1986-12-16
pubmed:abstractText
Epidural clonidine is reported to produce analgesia in humans. To investigate the effect of epidural injection of this alpha 2-adrenoceptor agonist on spinal cord blood flow as well as on regional and central blood flow and hemodynamics, 11 anesthetized pigs were studied. Each pig received clonidine in increments of 3, 10 and 30 micrograms/kg, each dose given in a volume of 5 ml via a lumbar epidural catheter. The tip of the catheter was located in the lumbar epidural space. The microsphere method was used to measure regional circulation. The measurements were made 45 min after each dose. Each pig served as its own control. The lowest dose of epidural clonidine (3 micrograms/kg) did not affect regional blood flow to the spinal cord or to any other organ. The intermediate and high doses were associated with local vasoconstriction in the lumbar and thoracic parts of the spinal cord that produced a statistically significant reduction in flow of 25-35% (P less than 0.05). Blood flow to the brain, cerebellum and the cervical parts of the spinal cord was not significantly changed, nor was renal blood flow. In the adrenal and in skeletal muscles a marked reduction of the blood flow occurred after the high dose, 61% and 78%, respectively. These findings indicate that epidural clonidine 3 micrograms/kg, a dose of clinical interest, is not likely to produce dangerous vasoconstriction in the spinal cord.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0003-2999
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1312-8
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Effect of epidural clonidine on spinal cord blood flow and regional and central hemodynamics in pigs.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't