Linked Life Data

3755623

Source:http://linkedlifedata.com/resource/pubmed/id/3755623

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-10-1
pubmed:abstractText
Elevated levels of a group of substances with digoxin-like immunoreactivity (DLIS) are present in biological fluids of newborns. These endogenous substances could also have the biological properties of cardiac glycosides, such as natriuretic and vasoconstrictor activity. Therefore, DLIS could be involved in electrolyte and volume regulation in infants. We measured DLIS, electrolyte (Na+, K+, Cl-) and creatinine concentrations in 157 urine samples collected from full-term and preterm infants, with the aim to establish if a correlation exists between the urinary DLIS levels and the respective values of these electrolytes. Significant and positive correlations were found between the urinary concentrations of DLIS and electrolytes. In addition, electrolyte values correlated significantly between themselves. DLIS, K+ and Cl- values correlated positively with urinary creatinine concentrations (n = 142). A significant multiple correlation was found among DLIS concentrations and creatinine and Cl- values. We also studied the DLIS concentrations in serum samples collected at birth in peripheral blood of the mothers and in umbilical cord and gastric aspirate of 5 full-term infants. We observed that DLIS values in newborns are significantly higher than the respective values of the mothers. In conclusion, our data do not demonstrate a clear relationship between DLIS and electrolyte concentrations in urine samples of newborns. Further investigations are necessary to elucidate the biochemical and physiological properties of DLIS.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0006-3126
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
27-35
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Correlations between digoxin-like immunoreactivity and electrolyte values in urinary samples of newborns.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't