Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1986-9-17
|
pubmed:abstractText |
These experiments were designed to characterize the nature and extent of diabetes insipidus present in a new model of genetic vasopressin (VP) deficiency, the Roman high avoidance rat homozygous for diabetes insipidus (RHA: di/di strain). The new strain was developed from an initial cross between Long-Evans derived Brattleboro (LE:di/di) rats and normal Roman high avoidance (RHA: +/+) rats, and has been bred to be congenic with the parent RHA: +/+ strain. RHA: di/di rats exhibited polydipsia, excreted dilute urine, and exhibited elevated plasma osmolality. RHA: di/di rats shows a similar urinary response to dehydration as LE: di/di rats. VP was undetectable by radioimmunoassay in the serum, brain, and neurohypophysis of RHA: di/di rats. VP-neurophysin containing cells were not observed in the brains of RHA: di/di rats upon immunocytochemical analysis. Thus, the new RHA: di/di strain exhibits essentially the same profile of diabetes insipidus as the LE: di/di rat. The congenic relationship between RHA: di/di and RHA: +/+ rats makes the RHA: di/di rat a useful model under circumstances where genetic variables unrelated to VP deficiency may confound the interpretation of data.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0028-3835
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
43
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
340-7
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:3736782-Animals,
pubmed-meshheading:3736782-Avoidance Learning,
pubmed-meshheading:3736782-Brain,
pubmed-meshheading:3736782-Brain Chemistry,
pubmed-meshheading:3736782-Crosses, Genetic,
pubmed-meshheading:3736782-Diabetes Insipidus,
pubmed-meshheading:3736782-Disease Models, Animal,
pubmed-meshheading:3736782-Female,
pubmed-meshheading:3736782-Heterozygote,
pubmed-meshheading:3736782-Homozygote,
pubmed-meshheading:3736782-Male,
pubmed-meshheading:3736782-Neurophysins,
pubmed-meshheading:3736782-Rats,
pubmed-meshheading:3736782-Rats, Mutant Strains,
pubmed-meshheading:3736782-Tissue Distribution,
pubmed-meshheading:3736782-Vasopressins
|
pubmed:year |
1986
|
pubmed:articleTitle |
Characterization of a new rodent model of diabetes insipidus: the Roman high avoidance rat homozygous for diabetes insipidus.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|