Linked Life Data

3732210

Source:http://linkedlifedata.com/resource/pubmed/id/3732210

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1986-9-17
pubmed:abstractText
Metallothionein (MT) levels were measured by radioimmunoassay in bronchoalveolar cells and fluids derived from rat lungs following 0, 8, 12, 18, or 24 exposures to Cd acetate aerosols. Alveolar cell metallothionein levels increased from a base line value of 0.35 micrograms MT/mg protein in control rats to a value of 21.73 micrograms MT/mg protein in rats exposed 24 times to Cd aerosols. Cell-free lavage fluid levels of metallothionein also increased in response to frequency of Cd exposure but were 5 to 10-fold lower than in the free alveolar cells. Gel chromatographic analysis of free alveolar cells from Cd-exposed animals revealed the presence of a 11,600-Da Cd-binding protein with an absorption maximum of 254 nm. Metallothionein analyses of purified populations of alveolar macrophages and polymorphonuclear leukocytes from exposed animals demonstrated that macrophages but not polymorphonuclear leukocytes contained metallothionein.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0013-9351
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
391-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Detection of metallothionein in bronchoalveolar cells and lavage fluid following repeated cadmium inhalation.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.