Linked Life Data

3608189

Source:http://linkedlifedata.com/resource/pubmed/id/3608189

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1987-8-28
pubmed:abstractText
The validation of a new assay for the leucine degradion product isovaleraldehyde in biological fluids is described. A gas purge technique was used with trapping of volatile constituents in a Tenax cartridge followed by automated thermal desorption and gas chromatographic analysis. The concentration of isovaleraldehyde during the course of hepatic encephalopathy (80 observations in 48 patients; 25 cirrhotic, 23 fulminant hepatic failure) was significantly increased compared to control subjects (0.58 +/- 0.08 compared to 0.17 +/- 0.02 mol/l; p less than 0.001). However, concentrations in grades 3-4 coma (37 observations) and grades 1-2 coma (30 observations) were similar and were not significantly different from values when encephalopathy was absent (grade 0; 13 observations). These results do not support an important role for isovaleraldehyde in the pathogenesis of hepatic encephalopathy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0009-8981
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
165
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
61-71
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Thermal desorption-gas chromatography of plasma isovaleraldehyde in hepatic encephalopathy in man.
pubmed:publicationType
Journal Article