Linked Life Data

3606389

Source:http://linkedlifedata.com/resource/pubmed/id/3606389

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1987-8-5
pubmed:abstractText
ICR male mice aged 5 weeks were injected subcutaneously with CdCl2, Pb(CH3COO)2, AgNO3, CuCl2, a combination of Cd and Ag compounds, or a combination of Cu and Ag compounds. These injections were carried out 3 times. Twenty-four hours after the last injection, they were sacrificed. Cd injection significantly stimulated serum ceruloplasmin (Cp) activity and Cu concentration, accompanied by an increase in hepatic Cu. Pb injection also slightly increased the Cp level. In contrast, Ag injection markedly decreased both Cp activity and Cu concentration in the serum. Hepatic Cu increased slightly after Ag injection. Using a combination of Cd and Ag, only the Ag effect on the Cp activity appeared. The Cu injection stimulated Cu binding to metallothionein (MT) and bile excretion of Cu, but not Cp release. With a Cu and Ag combination, the effect of Ag on Cp was lost, with a concomitant disappearance of Ag from the Cp fraction in the serum. Our results suggest that in the mouse, Cd and Ag, Cu antagonistic metals, influence different sites of Cp metabolism. Excess hepatic Cu is partly eliminated by excretion of bile and is partly detoxified by MT induction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0340-5761
pubmed:author
pubmed:issnType
Print
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
432-6
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Relationship between ceruloplasmin and Cu status involving metallothionein induced by several heavy metals in the mouse.
pubmed:publicationType
Journal Article