Linked Life Data

3585740

Source:http://linkedlifedata.com/resource/pubmed/id/3585740

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1987-7-17
pubmed:abstractText
An HPLC methodology is described which enables the quantitation of thiothixene (N,N-dimethyl-9-[3-(4-methyl-1-piperazinyl)-propylidene]thioxanthe ne-2- sulfonamide) in bulk drug, finished product, and dissolution samples using a single analytical column (SiAl: a mixture of silica and alumina). The Z (cis) and the less pharmacologically active E (trans) isomers of thiothixene, as well as synthetic precursors and degradants, are well resolved within a short chromatographic run. A minor modification of the mobile phase allows direct injection and quantitation of low-concentration samples in a simulated gastric fluid (SGF) dissolution medium. The method is capable of supplanting the three separate procedures currently included in the thiothixene monograph of the U.S. Pharmacopeia XXI.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-3549
pubmed:author
pubmed:issnType
Print
pubmed:volume
76
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
231-4
pubmed:dateRevised
2000-12-18
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Comprehensive high-performance liquid chromatographic methodology for the determination of thiothixene in bulk drug, finished product, and dissolution testing samples.
pubmed:publicationType
Journal Article