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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
|
pubmed:dateCreated |
1987-5-18
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pubmed:abstractText |
Since it has been demonstrated that a high level of fat is a dietary factor in the etiology of colon cancer, the effect of carrageenan, a polysaccharide extracted from the red seaweeds, on 1,2-dimethylhydrazine-induced colonic tumors in rats fed a semipurified control diet containing an ordinary level of fat was studied. Nevertheless, the enhancing effect of carrageenan on colonic tumors was observed. The rats fed a carrageenan diet had approximately twice the fecal weight compared to the rats fed a control diet. While no significant differences were found in beta-glucuronidase activities in colonic mucosa, liver or plasma in the carrageenan-fed rats and controls, the activity in feces was significantly lower in the carrageenan-fed rats. At least, no beta-glucuronidase activity seemed to be related to the tumor-enhancing effect of carrageenan.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1,2-Dimethylhydrazine,
http://linkedlifedata.com/resource/pubmed/chemical/Carrageenan,
http://linkedlifedata.com/resource/pubmed/chemical/Dimethylhydrazines,
http://linkedlifedata.com/resource/pubmed/chemical/Glucuronidase,
http://linkedlifedata.com/resource/pubmed/chemical/Methylhydrazines
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0301-4800
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
32
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
481-5
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:3559759-1,2-Dimethylhydrazine,
pubmed-meshheading:3559759-Animals,
pubmed-meshheading:3559759-Carrageenan,
pubmed-meshheading:3559759-Colonic Neoplasms,
pubmed-meshheading:3559759-Diet,
pubmed-meshheading:3559759-Dimethylhydrazines,
pubmed-meshheading:3559759-Drug Synergism,
pubmed-meshheading:3559759-Feces,
pubmed-meshheading:3559759-Glucuronidase,
pubmed-meshheading:3559759-Intestinal Mucosa,
pubmed-meshheading:3559759-Liver,
pubmed-meshheading:3559759-Methylhydrazines,
pubmed-meshheading:3559759-Rats,
pubmed-meshheading:3559759-Rats, Inbred F344
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pubmed:year |
1986
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pubmed:articleTitle |
Enhancing effect of carrageenan on the induction of rat colonic tumors by 1,2-dimethylhydrazine and its relation to beta-glucuronidase activities in feces and other tissues.
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pubmed:publicationType |
Journal Article
|