Linked Life Data

3554261

Source:http://linkedlifedata.com/resource/pubmed/id/3554261

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1987-6-23
pubmed:abstractText
Decreased microcirculatory flow in the case of endotoxic shock has been extensively reported. The flexibility of the red blood cell plays an important role in tissue perfusion. The present study with a canine shock model was designed to investigate the changes in erythrocyte flow properties during septic shock. Deformabilities of canine erythrocytes were found to decrease considerably 6 hr after infusion of Escherichia coli organisms (P less than 0.05). Pretreatment of dogs with pentoxifylline reduced the effect by improving erythrocyte deformability significantly and by increasing animal survival times. The leukotriene antagonist LY171883 also increased survival time, but did not change red cell filterability. The mortality of the dogs was not affected by either pentoxifylline or the leukotriene antagonist. Both drugs aided the concentration recovery of circulating leukocytes by 6 hr post-E. coli infusion.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0037-9727
pubmed:author
pubmed:issnType
Print
pubmed:volume
185
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
206-10
pubmed:dateRevised
2007-11-2
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Erythrocyte deformability in canine septic shock and the efficacy of pentoxifylline and a leukotriene antagonist.
pubmed:publicationType
Journal Article