Linked Life Data

3546501

Source:http://linkedlifedata.com/resource/pubmed/id/3546501

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1987-4-3
pubmed:abstractText
Investigations on porous and nonporous alloys currently available for surgical implant device stabilization through tissue ingrowth have shown microstructures that are characteristic of the thermal processing history of the device and alloy with differences between the nonporous and porous devices of the same nominal chemical analysis, in vitro corrosion potentials that are similar for porous and nonporous alloys and corrosion rates that are approximately proportional to the increases in relative surface areas (X 2 to X 10); local tissue interactions at the cellular level that are specific to the type and amount of elemental constituents present at the interface; and no direct correlations between the local cellular responses (fibroblasts) and the potential for hypersensitivity and other systemically mediated responses. Evaluations of the available published literature and available information on device retrievals and analyses support the opinion that no quantitative, statistically based epidemiologic studies have yet established significant correlations between selected metallic ions and major types of tissue lesions. However, with the changes in surface area and basic surface chemistry for existing alloy systems, research on the long-term tissue responses should be emphasized. In our opinion, biomaterial surface modifications are possible, whereby the relative quantities of released ions available to the environment could be significantly reduced.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-6895
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
258-61
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Corrosion and ion transfer from porous metallic alloys to tissues.
pubmed:publicationType
Journal Article