| pubmed-article:3540593 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3540593 | lifeskim:mentions | umls-concept:C1705597 | lld:lifeskim |
| pubmed-article:3540593 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:3540593 | lifeskim:mentions | umls-concept:C0459385 | lld:lifeskim |
| pubmed-article:3540593 | lifeskim:mentions | umls-concept:C0017638 | lld:lifeskim |
| pubmed-article:3540593 | lifeskim:mentions | umls-concept:C1882598 | lld:lifeskim |
| pubmed-article:3540593 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:3540593 | lifeskim:mentions | umls-concept:C0032200 | lld:lifeskim |
| pubmed-article:3540593 | lifeskim:mentions | umls-concept:C0015111 | lld:lifeskim |
| pubmed-article:3540593 | lifeskim:mentions | umls-concept:C0332293 | lld:lifeskim |
| pubmed-article:3540593 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:3540593 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:3540593 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:3540593 | pubmed:dateCreated | 1987-2-10 | lld:pubmed |
| pubmed-article:3540593 | pubmed:abstractText | Long-term culturing of brain cells from neonatal BD-IX rats after transplacental treatment with N-ethyl-N-nitrosourea (ENU) results in malignantly transformed cells after a lag period of about 250 days. During culturing, the brain cells undergo a sequence of morphological changes. We examined oncogene expression in cultured cells from ENU-treated animals and found that transformed glioma cells differ from premalignant glial cells by containing high levels of c-sis transcripts. We also report that the transformed cells synthesize functional platelet-derived growth factor. Because glial cells have receptors for platelet-derived growth factor, we propose that an autocrine mechanism plays an important role in ENU-induced brain tumorigenesis. | lld:pubmed |
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| pubmed-article:3540593 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3540593 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3540593 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3540593 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3540593 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:3540593 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:3540593 | pubmed:author | pubmed-author:NusseRR | lld:pubmed |
| pubmed-article:3540593 | pubmed:author | pubmed-author:LensP FPF | lld:pubmed |
| pubmed-article:3540593 | pubmed:author | pubmed-author:AltenaBB | lld:pubmed |
| pubmed-article:3540593 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3540593 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:3540593 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3540593 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3540593 | pubmed:pagination | 3537-40 | lld:pubmed |
| pubmed-article:3540593 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3540593 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3540593 | pubmed:articleTitle | Expression of c-sis and platelet-derived growth factor in in vitro-transformed glioma cells from rat brain tissue transplacentally treated with ethylnitrosourea. | lld:pubmed |
| pubmed-article:3540593 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3540593 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3540593 | lld:pubmed |
