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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0015111,
umls-concept:C0017262,
umls-concept:C0017638,
umls-concept:C0032200,
umls-concept:C0185117,
umls-concept:C0332293,
umls-concept:C0459385,
umls-concept:C1705597,
umls-concept:C1882598,
umls-concept:C2911684
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pubmed:issue |
10
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pubmed:dateCreated |
1987-2-10
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pubmed:abstractText |
Long-term culturing of brain cells from neonatal BD-IX rats after transplacental treatment with N-ethyl-N-nitrosourea (ENU) results in malignantly transformed cells after a lag period of about 250 days. During culturing, the brain cells undergo a sequence of morphological changes. We examined oncogene expression in cultured cells from ENU-treated animals and found that transformed glioma cells differ from premalignant glial cells by containing high levels of c-sis transcripts. We also report that the transformed cells synthesize functional platelet-derived growth factor. Because glial cells have receptors for platelet-derived growth factor, we propose that an autocrine mechanism plays an important role in ENU-induced brain tumorigenesis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540593-1206744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540593-2981413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540593-352535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540593-355894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540593-380651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540593-4237278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540593-4559710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540593-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540593-6086760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540593-6091919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540593-6095109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540593-6096004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540593-6171440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540593-6173755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540593-6304883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540593-6306134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540593-6306471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540593-6318746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540593-6323994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540593-6330739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540593-6373015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540593-6772444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540593-6943569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540593-7193676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3540593-7412807
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3537-40
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3540593-Animals,
pubmed-meshheading:3540593-Brain,
pubmed-meshheading:3540593-Brain Neoplasms,
pubmed-meshheading:3540593-Cell Transformation, Neoplastic,
pubmed-meshheading:3540593-Cells, Cultured,
pubmed-meshheading:3540593-Ethylnitrosourea,
pubmed-meshheading:3540593-Female,
pubmed-meshheading:3540593-Genes,
pubmed-meshheading:3540593-Glioma,
pubmed-meshheading:3540593-Maternal-Fetal Exchange,
pubmed-meshheading:3540593-Oncogenes,
pubmed-meshheading:3540593-Platelet-Derived Growth Factor,
pubmed-meshheading:3540593-Pregnancy,
pubmed-meshheading:3540593-Proto-Oncogene Proteins,
pubmed-meshheading:3540593-Proto-Oncogene Proteins c-sis,
pubmed-meshheading:3540593-Rats
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pubmed:year |
1986
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pubmed:articleTitle |
Expression of c-sis and platelet-derived growth factor in in vitro-transformed glioma cells from rat brain tissue transplacentally treated with ethylnitrosourea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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