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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1986-12-16
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pubmed:abstractText |
In a randomised study of two drugs for the oral treatment of uncomplicated urogenital and rectal gonorrhoea the therapeutic effect of cefuroxime axetil ester (CAE) and amoxycillin plus clavulanic acid (A + C) was compared. Cefuroxime axetil ester 1.5 g was given to 129 men and 118 women. Amoxycillin 3.0 g and clavulanic acid 0.25 g was given to 131 men and 122 women. Both treatments were combined with probenecid 1.0 g and administered in a single oral dose. Of the 500 patients thus treated, 376 were assessable. In the group taking CAE, failure rates were 0.9% for the men and 0% for the women; and the overall failure rate was 0.5%. In the group taking A + C the equivalent failure rates were 4.6%, 1.2%, and 3.1%. The differences were not significant. Penicillinase producing Neisseria gonorrhoeae (PPNG) was isolated from 5.6% of the assessable patients. All 10 PPNG infections in the group taking CAE and four of 11 PPNG infections in the group taking A + C were cured. These numbers were too small to draw a definite conclusion about the efficacy of both drugs in this type of infection. Postgonococcal urethritis was observed in 35% of the men in the group taking CAE and in 32% of those in the group taking A + C. Side effects were noted in 38% of the group taking CAE and 28% of the group taking A + C. Nausea and vomiting were more commonly observed in the group taking CAE; and diarrhoea was more commonly observed in the group taking A + C.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0266-4348
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
313-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3533755-Administration, Oral,
pubmed-meshheading:3533755-Adolescent,
pubmed-meshheading:3533755-Adult,
pubmed-meshheading:3533755-Amoxicillin,
pubmed-meshheading:3533755-Amoxicillin-Potassium Clavulanate Combination,
pubmed-meshheading:3533755-Cefuroxime,
pubmed-meshheading:3533755-Cephalosporins,
pubmed-meshheading:3533755-Clavulanic Acids,
pubmed-meshheading:3533755-Clinical Trials as Topic,
pubmed-meshheading:3533755-Drug Combinations,
pubmed-meshheading:3533755-Drug Therapy, Combination,
pubmed-meshheading:3533755-Female,
pubmed-meshheading:3533755-Gonorrhea,
pubmed-meshheading:3533755-Humans,
pubmed-meshheading:3533755-Male,
pubmed-meshheading:3533755-Middle Aged,
pubmed-meshheading:3533755-Probenecid,
pubmed-meshheading:3533755-Random Allocation
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pubmed:year |
1986
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pubmed:articleTitle |
Comparison of oral treatment of uncomplicated urogenital and rectal gonorrhoea with cefuroxime axetil ester or clavulanic acid potentiated amoxycillin (Augmentin).
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
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