Linked Life Data

3527250

Source:http://linkedlifedata.com/resource/pubmed/id/3527250

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1986-10-3
pubmed:abstractText
Intranasal (or intratracheal) administration of a tissue-destructive protease from Legionella pneumophila to guinea-pigs produced areas of haemorrhagic pneumonia in the lungs after 1/2 h. By 24 h there was confluent consolidation in all lobes. Histological and ultrastructural studies showed alveolar haemorrhage, vesiculation and necrosis of type I alveolar epithelium and endothelium, followed by progressive exudation of oedema fluid, fibrin, PMN and macrophages. Damage to type II cell lamellated bodies and discharge of lamellar material were significant features of the lesion. Collagenase activity was indicated by morphological degradation of collagen fibres in severely affected interalveolar septa. The pathological changes of Legionnaires' disease pneumonia can thus be reproduced experimentally by the administration of a L. pneumophila tissue-destructive protease, suggesting that production of this protease in vivo during L. pneumophila infection may play an important role in causing the pneumonia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0007-1021
pubmed:author
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
527-36
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Pulmonary damage caused by a protease from Legionella pneumophila.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't