| pubmed-article:3520561 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3520561 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:3520561 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:3520561 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:3520561 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:3520561 | lifeskim:mentions | umls-concept:C1998793 | lld:lifeskim |
| pubmed-article:3520561 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:3520561 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:3520561 | pubmed:dateCreated | 1986-7-9 | lld:pubmed |
| pubmed-article:3520561 | pubmed:abstractText | Mouse tumor necrosis factor (TNF) was purified from serum through a series of steps, and each step was monitored for L-cell cytotoxicity in vitro and tumor-necrotizing activity in vivo. The two activities copurified and could not be dissociated. Purified mouse TNF has a specific activity of 2.2 X 10(7) (L-cell assay in the absence of actinomycin D) and 1 microgram causes necrosis of the standard TNF-sensitive sarcoma Meth A. TNF has a Mr of 39,000 +/- 2000 by gel filtration and a Mr of 16,000-18,000 by NaDodSO4/PAGE. Both molecular weight forms display cytotoxic and necrotizing activities. TNF has a pI of 3.9 and is destroyed by trypsin, protease, elastase, and alpha-chymotrypsin but not by neuraminidase or papain. These characteristics of nonrecombinant mouse TNF clearly resemble those of recombinant human and mouse TNF. | lld:pubmed |
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| pubmed-article:3520561 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3520561 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3520561 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3520561 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3520561 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:3520561 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:3520561 | pubmed:author | pubmed-author:OldL JLJ | lld:pubmed |
| pubmed-article:3520561 | pubmed:author | pubmed-author:CarswellE AEA | lld:pubmed |
| pubmed-article:3520561 | pubmed:author | pubmed-author:HaranakaKK | lld:pubmed |
| pubmed-article:3520561 | pubmed:author | pubmed-author:SatomiNN | lld:pubmed |
| pubmed-article:3520561 | pubmed:author | pubmed-author:PrendergastJ... | lld:pubmed |
| pubmed-article:3520561 | pubmed:author | pubmed-author:WilliamsonB... | lld:pubmed |
| pubmed-article:3520561 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3520561 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:3520561 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3520561 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3520561 | pubmed:pagination | 3949-53 | lld:pubmed |
| pubmed-article:3520561 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3520561 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3520561 | pubmed:articleTitle | Purification, characterization, and antitumor activity of nonrecombinant mouse tumor necrosis factor. | lld:pubmed |
| pubmed-article:3520561 | pubmed:publicationType | Journal Article | lld:pubmed |
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