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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1986-6-16
|
| pubmed:abstractText |
Ulex europaeus agglutinin-I (UEA-I) recognizes the Fuc alpha 1----2 Gal linkage. Receptors for UEA-I were not detected in mouse embryos until the 13th day of embryo-genesis, except for their temporary expression in early trophectoderm cells. In adult mice, UEA-I receptors were detected at various sites, including cells of the digestive tracts, the bronchial epithelium, Hassall's corpuscle of the thymus, and the skin. The fucose-binding protein of Lotus tetragonolobus (FBP) is another lectin that recognizes fucosyl residues. The distribution of FBP receptors was significantly different from that of UEA-I receptors. FBP receptors were first detected in late 8-cell embryos and were expressed in the embryonic ectoderm, visceral endoderm, and trophoblastic giant cells in egg-cylinders. At later stages, the distribution of FBP receptors became restricted to certain parts of the embryo. In the adult, the distribution of FBP receptors was more restricted than that of UEA-I receptors. Particularly in embryos before the 11th day of gestation, the distribution of FBP receptors resembled that of SSEA-1, which is defined by the Gal beta 1----4(Fuc alpha 1----3) GlcNAc linkage. From the specificity of FBP, we inferred that the disappearance of SSEA-1 and FBP receptors during embryogenesis is not the result of alpha 1----2 fucosylation of the terminal galactosyl residue in the determinant. The fact that the expression of two fucose-related cell-surface markers, i.e., UEA-I receptors and SSEA-1 (or FBP receptors), is developmentally regulated in an entirely different fashion is an excellent example illustrating the precise control of differentiation-dependent alterations in cell-surface carbohydrates.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Fucose,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Lectins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Mitogen,
http://linkedlifedata.com/resource/pubmed/chemical/Ulex europaeus lectins,
http://linkedlifedata.com/resource/pubmed/chemical/fucose-binding lectin
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0301-4681
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
30
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
211-9
|
| pubmed:dateRevised |
2008-8-19
|
| pubmed:meshHeading |
pubmed-meshheading:3516778-Aging,
pubmed-meshheading:3516778-Animals,
pubmed-meshheading:3516778-Cell Transformation, Neoplastic,
pubmed-meshheading:3516778-Embryonic Development,
pubmed-meshheading:3516778-Embryonic and Fetal Development,
pubmed-meshheading:3516778-Female,
pubmed-meshheading:3516778-Fluorescent Antibody Technique,
pubmed-meshheading:3516778-Fucose,
pubmed-meshheading:3516778-Immunoenzyme Techniques,
pubmed-meshheading:3516778-Lectins,
pubmed-meshheading:3516778-Mice,
pubmed-meshheading:3516778-Mice, Inbred C3H,
pubmed-meshheading:3516778-Mice, Inbred C57BL,
pubmed-meshheading:3516778-Mice, Inbred ICR,
pubmed-meshheading:3516778-Organ Specificity,
pubmed-meshheading:3516778-Plant Lectins,
pubmed-meshheading:3516778-Pregnancy,
pubmed-meshheading:3516778-Receptors, Mitogen,
pubmed-meshheading:3516778-Teratoma
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Differential distribution of receptors for two fucose-binding lectins in embryos and adult tissues of the mouse.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|