| pubmed-article:3495801 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3495801 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:3495801 | lifeskim:mentions | umls-concept:C0003323 | lld:lifeskim |
| pubmed-article:3495801 | lifeskim:mentions | umls-concept:C0003242 | lld:lifeskim |
| pubmed-article:3495801 | lifeskim:mentions | umls-concept:C1145667 | lld:lifeskim |
| pubmed-article:3495801 | lifeskim:mentions | umls-concept:C1176299 | lld:lifeskim |
| pubmed-article:3495801 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:3495801 | pubmed:dateCreated | 1987-7-8 | lld:pubmed |
| pubmed-article:3495801 | pubmed:abstractText | A monoclonal anti-idiotypic (anti-Id) antibody, HF1.7, was generated against anti-Leu-3a, a mouse monoclonal antibody (mAb) specific for the CD4 molecule on human helper/inducer T lymphocytes. The anti-Id nature of HF1.7 was demonstrated by the following properties. (i) It reacted in a solid-phase immunoassay with anti-Leu-3a and not with a panel of irrelevant mouse mAbs. (ii) It partially inhibited the binding of anti-Leu-3a to CD4+ T cells. (iii) It detected a common idiotype present on various anti-CD4 mAbs. Because the CD4 molecule represents the receptor site for human immunodeficiency virus (HIV), the etiologic viral agent of acquired immunodeficiency syndrome, we examined the ability of the anti-mAb HF1.7 to mimic CD4 and bind HIV. This anti-Id mAb reacted with HIV antigens in commercial HIV ELISAs and recognized HIV-infected human T cells but not uninfected cells when analyzed by flow cytofluorometry. Attesting further to the HIV specificity, the anti-Id mAb reacted with a recombinant gp160 peptide and a molecule of Mr 110,000-120,000 in immunoblot analysis of HIV-infected cell lysates. The anti-Id mAb also partially neutralized HIV infection of human T cells in vitro. These results strongly suggest that this anti-Id mAb mimics the CD4 antigenic determinants involved in binding to HIV. | lld:pubmed |
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| pubmed-article:3495801 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3495801 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3495801 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3495801 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3495801 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:3495801 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:3495801 | pubmed:author | pubmed-author:DreesmanG RGR | lld:pubmed |
| pubmed-article:3495801 | pubmed:author | pubmed-author:ChanhT CTC | lld:pubmed |
| pubmed-article:3495801 | pubmed:author | pubmed-author:KennedyR CRC | lld:pubmed |
| pubmed-article:3495801 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3495801 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:3495801 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3495801 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3495801 | pubmed:pagination | 3891-5 | lld:pubmed |
| pubmed-article:3495801 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3495801 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3495801 | pubmed:articleTitle | Monoclonal anti-idiotypic antibody mimics the CD4 receptor and binds human immunodeficiency virus. | lld:pubmed |
| pubmed-article:3495801 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3495801 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3495801 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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