| pubmed-article:3495006 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3495006 | lifeskim:mentions | umls-concept:C0012634 | lld:lifeskim |
| pubmed-article:3495006 | lifeskim:mentions | umls-concept:C0079784 | lld:lifeskim |
| pubmed-article:3495006 | lifeskim:mentions | umls-concept:C0018951 | lld:lifeskim |
| pubmed-article:3495006 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:3495006 | lifeskim:mentions | umls-concept:C0008668 | lld:lifeskim |
| pubmed-article:3495006 | lifeskim:mentions | umls-concept:C0449721 | lld:lifeskim |
| pubmed-article:3495006 | lifeskim:mentions | umls-concept:C1442161 | lld:lifeskim |
| pubmed-article:3495006 | lifeskim:mentions | umls-concept:C0439677 | lld:lifeskim |
| pubmed-article:3495006 | lifeskim:mentions | umls-concept:C0009085 | lld:lifeskim |
| pubmed-article:3495006 | lifeskim:mentions | umls-concept:C1516050 | lld:lifeskim |
| pubmed-article:3495006 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:3495006 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:3495006 | lifeskim:mentions | umls-concept:C1998811 | lld:lifeskim |
| pubmed-article:3495006 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:3495006 | pubmed:dateCreated | 1987-6-9 | lld:pubmed |
| pubmed-article:3495006 | pubmed:abstractText | The CSF-1 gene encodes a hematopoietic colony-stimulating factor (CSF) that promotes growth, differentiation, and survival of mononuclear phagocytes. By using somatic cell hybrids and in situ hybridization, we localized this gene to human chromosome 5 at bands q31 to q35, a chromosomal region that is frequently deleted [del(5q)] in patients with myeloid disorders. By in situ hybridization, the CSF-1 gene was found to be deleted in the 5q- chromosome of a patient with refractory anemia who had a del(5)(q15q33.3) and in that of a second patient with acute nonlymphocytic leukemia de novo who had a similar distal breakpoint [del(5)(q13q33.3)]. The gene was present in the deleted chromosome of a third patient, with therapy-related acute nonlymphocytic leukemia, who had a more proximal breakpoint in band q33 [del(5)(q22q33.1)]. Hybridization of the CSF-1 probe to metaphase cells of a fourth patient, with acute nonlymphocytic leukemia de novo, who had a rearrangement of chromosomes 5 and 21 [ins(21;5)(q22;q31.3q33.1)] resulted in labeling of the breakpoint junctions of both rearranged chromosomes; this suggested that CSF-1 is located at 5q33.1. Thus, a small segment of chromosome 5 contains GM-CSF (the gene encoding the granulocyte-macrophage CSF), CSF-1, and FMS, which encodes the CSF-1 receptor, in that order from the centromere; this cluster of genes may be involved in the altered hematopoiesis associated with a deletion of 5q. | lld:pubmed |
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| pubmed-article:3495006 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3495006 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3495006 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3495006 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3495006 | pubmed:month | May | lld:pubmed |
| pubmed-article:3495006 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:3495006 | pubmed:author | pubmed-author:SherrC JCJ | lld:pubmed |
| pubmed-article:3495006 | pubmed:author | pubmed-author:RowleyJ DJD | lld:pubmed |
| pubmed-article:3495006 | pubmed:author | pubmed-author:LemonsR SRS | lld:pubmed |
| pubmed-article:3495006 | pubmed:author | pubmed-author:LarsonR ARA | lld:pubmed |
| pubmed-article:3495006 | pubmed:author | pubmed-author:DiazM OMO | lld:pubmed |
| pubmed-article:3495006 | pubmed:author | pubmed-author:KawasakiE SES | lld:pubmed |
| pubmed-article:3495006 | pubmed:author | pubmed-author:Le BeauM MMM | lld:pubmed |
| pubmed-article:3495006 | pubmed:author | pubmed-author:PettenatiM... | lld:pubmed |
| pubmed-article:3495006 | pubmed:author | pubmed-author:ShimaE AEA | lld:pubmed |
| pubmed-article:3495006 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3495006 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:3495006 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3495006 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3495006 | pubmed:pagination | 2970-4 | lld:pubmed |
| pubmed-article:3495006 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3495006 | pubmed:meshHeading | pubmed-meshheading:3495006-... | lld:pubmed |
| pubmed-article:3495006 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3495006 | pubmed:articleTitle | Assignment of CSF-1 to 5q33.1: evidence for clustering of genes regulating hematopoiesis and for their involvement in the deletion of the long arm of chromosome 5 in myeloid disorders. | lld:pubmed |
| pubmed-article:3495006 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3495006 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3495006 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:3495006 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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