Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1987-6-9
pubmed:abstractText
The CSF-1 gene encodes a hematopoietic colony-stimulating factor (CSF) that promotes growth, differentiation, and survival of mononuclear phagocytes. By using somatic cell hybrids and in situ hybridization, we localized this gene to human chromosome 5 at bands q31 to q35, a chromosomal region that is frequently deleted [del(5q)] in patients with myeloid disorders. By in situ hybridization, the CSF-1 gene was found to be deleted in the 5q- chromosome of a patient with refractory anemia who had a del(5)(q15q33.3) and in that of a second patient with acute nonlymphocytic leukemia de novo who had a similar distal breakpoint [del(5)(q13q33.3)]. The gene was present in the deleted chromosome of a third patient, with therapy-related acute nonlymphocytic leukemia, who had a more proximal breakpoint in band q33 [del(5)(q22q33.1)]. Hybridization of the CSF-1 probe to metaphase cells of a fourth patient, with acute nonlymphocytic leukemia de novo, who had a rearrangement of chromosomes 5 and 21 [ins(21;5)(q22;q31.3q33.1)] resulted in labeling of the breakpoint junctions of both rearranged chromosomes; this suggested that CSF-1 is located at 5q33.1. Thus, a small segment of chromosome 5 contains GM-CSF (the gene encoding the granulocyte-macrophage CSF), CSF-1, and FMS, which encodes the CSF-1 receptor, in that order from the centromere; this cluster of genes may be involved in the altered hematopoiesis associated with a deletion of 5q.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-2408759, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-2420009, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-2877398, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-2990035, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-2996129, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-2999978, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-300377, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-3020426, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-3025863, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-313570, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-3484805, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-3484837, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-3517860, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-3523756, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-3878229, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-3891074, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-3923623, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-3950675, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-4005429, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-4028159, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-4421285, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-6092965, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-6190911, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-6319012, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-6320372, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-6329026, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-6632085, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-6722761, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-6733676, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-6756627, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-7272506, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-7336163, http://linkedlifedata.com/resource/pubmed/commentcorrection/3495006-80284
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2970-4
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Assignment of CSF-1 to 5q33.1: evidence for clustering of genes regulating hematopoiesis and for their involvement in the deletion of the long arm of chromosome 5 in myeloid disorders.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't