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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1987-5-6
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pubmed:abstractText |
We examined the in vivo effects of recombinant human granulocyte colony-stimulating factor (rhG-CSF) in primates (cynomolgus monkeys) treated with subcutaneous doses of rhG-CSF for 14-28 d. A dose-dependent increase in the peripheral white blood cells (WBC) was seen, reaching a plateau after 1 wk of rhG-CSF treatment. The elevation of WBC was due to an increase in the absolute neutrophil count. These results demonstrate that rhG-CSF is a potent granulopoietic growth and differentiation factor in vivo. In cyclophosphamide (CY)-induced myelosuppression, rhG-CSF was able to shorten the time period of WBC recovery in two treated monkeys to 1 wk, as compared to more than 4 wk for the control monkey. Its ability to significantly shorten the period of chemotherapy-induced bone marrow hypoplasia may allow clinicians to increase the frequency or dosage of chemotherapeutic agents. In addition, the increase in absolute numbers of functionally active neutrophils may have a profound effect in the rate and severity of neutropenia-related sepsis. Furthermore, the activities reported here indicate a potential role for rhG-CSF in the treatment of patients with myelodysplastic syndrome, congenital agranulocytosis, radiation-induced myelosuppression, and bone marrow transplantation.
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pubmed:grant | |
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3494094-13872176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3494094-2999287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3494094-3492428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3494094-3492429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3494094-3871951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3494094-4190452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3494094-6308055
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-1007
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
165
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
941-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3494094-Animals,
pubmed-meshheading:3494094-Bone Marrow,
pubmed-meshheading:3494094-Colony-Stimulating Factors,
pubmed-meshheading:3494094-Cyclophosphamide,
pubmed-meshheading:3494094-Granulocytes,
pubmed-meshheading:3494094-Hematopoiesis,
pubmed-meshheading:3494094-Humans,
pubmed-meshheading:3494094-Macaca fascicularis,
pubmed-meshheading:3494094-Macrophages,
pubmed-meshheading:3494094-Neutrophils,
pubmed-meshheading:3494094-Pancytopenia,
pubmed-meshheading:3494094-Recombinant Proteins,
pubmed-meshheading:3494094-Spleen
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pubmed:year |
1987
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pubmed:articleTitle |
Recombinant human granulocyte colony-stimulating factor. Effects on hematopoiesis in normal and cyclophosphamide-treated primates.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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